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| c. 1470 |
| | | Sandro Botticelli is established as one of the leading painters of Florence, working in particular for the Medici | |
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| 1472 |
| | | Leonardo da Vinci joins the painters' guild in Florence, probably after training with Verrocchio | |
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| c. 1475 |
| | | Giovanni Bellini becomes the key figure in the development of the Renaissance style in Venice | |
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| c. 1480 |
| | | Botticelli paints the Birth of Venus and Spring for the villa of a Medici cousin of Lorenzo the Magnificent | |
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| c. 1489 |
| | | Leonardo da Vinci begins an unprecedented series of detailed anatomical drawings, based on corpses dissected in Rome | |
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| 1499 |
| | | 24-year-old Michelangelo provides for St Peter's in Rome an exquisite Pietà – the Virgin holding on her lap the dead Christ | |
|  | Pietà Michelangelo
Fotofile CG
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| c. 1500 |
| | | Faenza becomes the main centre for the production of the Italian tin-glazed earthenware known as majolica | |
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| c. 1500 |
| | | Ceramic artists in Italy decorate large majolica dishes with scenes of narrative history, giving this style the name istoriato | |
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| 1501 |
| | | Michelangelo begins work in Florence on a tall thin slab of marble, which he transforms into David | |
|  | David Michelangelo
Fotofile CG
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| c. 1505 |
| | | Leonardo captures the enigmatic smile of Lisa Gherardini, known now as the Mona Lisa | |
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